Date of Award


Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)


Biomedical Engineering

First Advisor

Linehan, John, H.

Second Advisor

Dawson, Christopher A.

Third Advisor

Hamilton, Lyle H.


The problem investigated is the significance of respired gas density during maximum expiratory flow. Changes in maximum flow are studied during altered experimental conditions for dogs. Simulations from a mathematical model are employed to further elucidate mechanisms occurring during altered lung conditions. Simulations and experimental results are used to further understanding of patho-physiological mechanisms. Chapter 1 presents a survey of background information and pertinant [sic] literature. Chapter 2 discusses various aspects of the mathematical model, assumptions and sensitivity of model parameters. Experimental methods are presented in Chapter 3. Chapter 4 describes experimental results. Model simulations of altered airway diameter and compliance are given in Chapter 5. Chapter 6 discusses experimental results and simulation along with supporting evidence from the literature. The conclusion is presented in Chapter 7.



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