Conjugated Linoleic Acid Preserves Muscle Mass in Mice Bearing the Colon-26 Adenocarcinoma
Format of Original
Research in Nursing and Health
Original Item ID
doi: 10.1002/nur.20052; Shelves: RT1 .R48x Raynor Memorial Periodicals
Cancer cachexia is a syndrome of weight loss, muscle wasting, fatigue, and anorexia that occurs in patients with advanced or recurrent solid tumor disease. Tumor necrosis factor-alpha (TNFα) and prostaglandin E2 (PGE2) have been implicated in the biology of cachexia and serve as possible targets for treatment of this condition. Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid that alters the synthesis of PGE2 and reduces the negative effects of TNF on body weight of healthy mice. We hypothesized that a diet supplemented with .5% CLA might reduce muscle wasting in mice bearing the colon-26 adenocarcinoma, an animal model of cancer cachexia. CLA preserved gastrocnemius muscle mass and reduced TNF receptors in muscle of tumor-bearing mice. These data suggest that CLA may preserve muscle mass by reducing the catabolic effects of TNF on skeletal muscle. © 2004 Wiley Periodicals, Inc. Res Nurs Health 28:48–55, 2005
Graves, Erin; Hitt, Andrew; Pariza, Michael W.; Cook, Mark E.; and McCarthy, Donna O., "Conjugated Linoleic Acid Preserves Muscle Mass in Mice Bearing the Colon-26 Adenocarcinoma" (2005). College of Nursing Faculty Research and Publications. 192.