Wissam Deeb, University of Florida
Peter J. Rossi, University of Florida
Mauro Porta, Galeazzi Hospital, Milan, Italy
Veerle Visser-Vandewalle, University of Cologne
Domenico Servello, IRCCS Galeazzi, Milan Italy
Peter Silburn, University of Queensland
Terry Coyne, University of Queensland
James F. Leckman, Yale University
Thomas Foltynie, University College London Institute of Neurology
Marwan Hariz, University College London Institute of Neurology
Eileen M. Joyce, University College London Institute of Neurology
Ludvic Zrinzo, University College London Institute of Neurology
Zinovia Kefalopoulou, University College London Institute of Neurology
Marie-Laure Welter, Hôpital Pitié-Salpêtrière, Paris, France
Carine Karachi, Hôpital de la Pitié-Salpêtrière, Paris, France
Luc Mallet, Geneva University Hospital
Jean-Luc Houeto, Université de Poitiers
Joohi Shahed-Jimenez, Baylor College of Medicine
Fan-Gang Meng, Capital Medical University, Beijing, China
Brian T. Klassen, Mayo Clinic College of Medicine
Alan Y. Mogilner, New York University Medical Center
Michael H. Pourfar, New York University Medical Center
Jens Kuhn, University of Cologne
L. Ackermans, Maastricht University Medical Center
Takanobu Kaido, National Center of Neurology and Psychiatry, Kodaira, Japan
Yasin Temel, Maastricht University
Robert E. Gross, Emory University
Harrison C. Walker, University of Alabama, Birmingham
Andres M. Lozano, University of Toronto
Suketu M. Khandhar, Movement Disorders Program, Sacramento, USA
Benjamin L. Walter, Case Western Reserve University
Ellen Walter, University Hospitals Case Medical Center
Zoltan Mari, Johns Hopkins University
Barbara K. Changizi, The Ohio State University Wexner Medical Center
Elena Moro, Grenoble Alpes University
Juan C. Baldermann, Universitätsklinikum Köln
Daniel Huys, Universitätsklinikum Köln
S. Elizabeth Zauber, Indiana University
Lauren E. Schrock, University of Utah
Jian-Guo Zhang, Capital Medical University, Beijing, China
Wei Hu, University of Florida
Kelly D. Foote, University of Florida
Kyle Rizer, University of Florida
Jonathan W. Mink, University of Rochester Medical Center
Douglas W. Woods, Marquette UniversityFollow
Aysegul Gunduz, University of Florida
Michael S. Okun, University of FloridaFollow

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10 p.

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Frontiers Media S.A.

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Frontiers in Neuroscience

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DOI: 10.3389/fnins.2016.00170


Tourette Syndrome (TS) is a neuropsychiatric disease characterized by a combination of motor and vocal tics. Deep brain stimulation (DBS), already widely utilized for Parkinson's disease and other movement disorders, is an emerging therapy for select and severe cases of TS that are resistant to medication and behavioral therapy. Over the last two decades, DBS has been used experimentally to manage severe TS cases. The results of case reports and small case series have been variable but in general positive. The reported interventions have, however, been variable, and there remain non-standardized selection criteria, various brain targets, differences in hardware, as well as variability in the programming parameters utilized. DBS centers perform only a handful of TS DBS cases each year, making large-scale outcomes difficult to study and to interpret. These limitations, coupled with the variable effect of surgery, and the overall small numbers of TS patients with DBS worldwide, have delayed regulatory agency approval (e.g., FDA and equivalent agencies around the world). The Tourette Association of America, in response to the worldwide need for a more organized and collaborative effort, launched an international TS DBS registry and database. The main goal of the project has been to share data, uncover best practices, improve outcomes, and to provide critical information to regulatory agencies. The international registry and database has improved the communication and collaboration among TS DBS centers worldwide. In this paper we will review some of the key operation details for the international TS DBS database and registry.


Published version. Frontiers in Neuroscience, Vol. 10 (April 2016). DOI. © 2016 Deeb, Rossi, Porta, et al. Used with permission.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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