Authors

Leonardo F. Fontenelle, Monash University
Erin Oldenhof, Monash University
Maria Eduarda Moreira-de-Oliveira, Federal University of Rio de Janeiro
Jonathan S. Abramowitz, University of North Carolina at Chapel Hill
Martin M. Antony, Ryerson University
Danielle Cath, Rijksuniversity Groningen
Adrian Carter, Monash University
Darin D. Dougherty, Massachusetts General Hospital
Ygor A. Ferrao, Federal University of Health Sciences of Porto Alegre (UFCSPA)
Martijn Figee, University of Amsterdam
Ben J. Harrison, University of Melbourne
Marcelo Hoexter, Universidade de São Paulo
Jun Soo Kwon, Seoul National University
Anne Küelz, University of Freiburg
Luisa Lazaro, University of Barcelona
Christine Lochner, Stellenbosch University
Donatella Marazziti, University of Pisa
David Mataix-Cols, Karolinska Institutet
Dean McKay, Fordham University
Euripedes C. Miguel, Universidade de São Paulo
Sharon Morein-Zamir, Anglia Ruskin University
Steffen Mortiz, University Medical Center Hamburg-Eppendorf
Gerald Nestadt, Johns Hopkins University
Kieron O'Connor, University of Montreal
Stefano Pallanti, Stanford University Medical Center
Christine Purdon, University of Waterloo
Scott Rauch, McLean Hospital
Peggy Richter, University of Toronto
Jean-Yves Rotge, Sorbonne Universite
Roseli G. Shavitt, Universidade de São Paulo
Carles Soriano-Mas, Universitat Autònoma de Barcelona
Vladan Starcevic, University of Sydney
Dan J. Stein, University of Cape Town
Gail Steketee, Boston University
Eric A. Storch, Baylor College of Medicine
Steven Taylor, Baylor College of Medicine
Odile A. van den Heuvel, Vrije Universiteit
David Veale, King's College London
Douglas W. Woods, Marquette UniversityFollow
Antonio Verdejo-Garcia, Monash University
Murat Yucel, Monash University

Document Type

Article

Publication Date

7-2020

Publisher

SAGE Publications

Source Publication

Australian & New Zealand Journal of Psychiatry

Source ISSN

0004-8674

Abstract

Background:

The Research Domain Criteria seeks to bridge knowledge from neuroscience with clinical practice by promoting research into valid neurocognitive phenotypes and dimensions, irrespective of symptoms and diagnoses as currently conceptualized. While the Research Domain Criteria offers a vision of future research and practice, its 39 functional constructs need refinement to better target new phenotyping efforts. This study aimed to determine which Research Domain Criteria constructs are most relevant to understanding obsessive-compulsive and related disorders, based on a consensus between experts in the field of obsessive-compulsive and related disorders.

Methods:

Based on a modified Delphi method, 46 experts were recruited from Australia, Africa, Asia, Europe and the Americas. Over three rounds, experts had the opportunity to review their opinion in light of feedback from the previous round, which included how their response compared to other experts and a summary of comments given.

Results:

Thirty-four experts completed round one, of whom 28 (82%) completed round two and 24 (71%) completed round three. At the final round, four constructs were endorsed by ⩾75% of experts as ‘primary constructs’ and therefore central to understanding obsessive-compulsive and related disorders. Of these constructs, one came from the Positive Valence System (Habit), two from the Cognitive Control System (Response Selection/Inhibition and Performance Monitoring) and the final construct was an additional item suggested by experts (Compulsivity).

Conclusion:

This study identified four Research Domain Criteria constructs that, according to experts, cut across different obsessive-compulsive and related disorders. These constructs represent key areas for future investigation, and may have potential implications for clinical practice in terms of diagnostic processes and therapeutic management of obsessive-compulsive and related disorders.

Comments

Accepted version. Australian & New Zealand Journal of Psychiatry, Vol. 54, No. 7 (July 2020): 719-731. DOI. © 2020 SAGE Publications. Used with permission.

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