Date of Award

Spring 1990

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)



First Advisor

Ferguson, Donald J.

Second Advisor

Eslami, Ahmad

Third Advisor

Meyer, Ralph A.


The objective of this study was to determine 1) whether there were differences in the rate of cuspid retraction between the maxilla and the mandible and 2) whether the local intra-ligamental administration of interleukin-1 (IL-l), one of the most potent osteoclast activators, could accelerate the orthodontic tooth movement in ferrets (Mustela putorius). Adult male albino ferrets were used as test animals. In the pilot study, five animals had 0.008 x 0.036 inch, closed coil orthodontic light-wire retraction springs placed in the maxillary arch from the canine to the third premolar, and in the mandibular arch from the canine, to the first molar. The first and second premolars were previously extracted to create enough room for retraction of the cuspids. The appliance was calibered to deliver a force level of 80 grams and reactivated once a week. Three tooth movement measurements were made on a weekly basis using tooth-borne reference points. The magnitude of maxillary cuspid retraction was statistically greater than mandibular cuspid retraction at several time points. The main study consisted of five ferrets; orthodontic retraction springs were placed only in the maxillary quadrants. The right canines received Il-1 injections into the distal portion of the periodontal membrane and the left canines received the same amount of a pyrogen free phosphate-buffered saline. The injections and measurements were made on a weekly basis. No statistical differences in rate or magnitude of tooth movement were found between the control and IL-1 injected sides.



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