Date of Award

Summer 1978

Degree Type

Thesis - Restricted

Degree Name

Master of Science (MS)




Lipid represents a major source of energy during activity and body lipid stores undergo a seasonal cycle closely correlating with seasonal ovarian development in teleostean fishes. Lipids are stored in body muscle, liver or mesenteries in fish during the late summer and fall months; these energy stores are mobilized during the winter months for survival and gonadal development. Little is known concerning the endocrine control of teleost lipid metabolism. Since lipid storage is frequently correlated with the ovarian cycle, it is possible that ovarian sex steroids might be involved in the mobilization of stored fat. Estrogen has been implicated in lipid mobilization from body stores and in inducing new lipid synthesis in the liver. In teleosts, the liver plays an important role in lipid synthesis. The potential role of estradiol-17p in regulating certain aspects of lipid metabolism in the golden shiner Notemigonus crysoleucas were studied. This study was initiated to examine the effect of estradiol-17p on liver lipid metabolism, both in vivo and in vitro. Hepatic carbohydrate levels were also studied and its relevance to lipid metabolism discussed.