Date of Award

Spring 2010

Document Type


Degree Name

Master of Science (MS)


Biomedical Engineering

First Advisor

Gilat-Schmidt, Taly

Second Advisor

Ropella, Kristina

Third Advisor



Cardiac resynchronization therapy (CRT) has a high percentage of non-responders. Successfully locating the optimal location for CRT lead placement on a priori images can increase efficiency in procedural preparation and execution and could potentially increase the rate of CRT responders.

Registration has been used in the past to assess the motion of medical images. Specifically, one method of non-rigid registration has been utilized to assess the motion of left ventricular MR cardiac images. As CT imaging is often performed as part of resynchronization treatment planning and is a fast and accessible means of imaging, extending this registration method to assessing left ventricular motion of CT images could provide another means of reproducible contractility assessment.

This thesis investigates the use of non-rigid registration to evaluate the myocardium motion in multi-phase multi-slice computed tomography (MSCT) cardiac imaging for the evaluation of mechanical contraction of the left ventricle.