Simulation of the Segmental Burst Generating Network for Locomotion in Lamprey

Authors

Stan Grillner, Karolinska InstituteFollow
James T. Buchanan, Marquette UniversityFollow
A. Lansner, Karolinska Institute

Document Type

Article

Language

eng

Format of Original

5 p.

Publication Date

2014

Publisher

Elsevier

Source Publication

Neuroscience Letters

Source ISSN

0304-3940

Abstract

Recently a segmental network of inhibitory and excitatory interneurones, which are active during locomotion, has been described in the lamprey, a lower vertebrate. The interactions between the different neurones were established by paired intracellular recordings. A computer simulation of the segmental network has been performed, which shows that with the established neuronal connectivity rhythmic alternating burst activity can be generated within the upper part of the normal physiological range of locomotion. Three neurones of each kind were used (altogether 18 neurones). As shown previously the lower frequency range used in locomotion most likely depends on an activation of voltage-dependent (NMDA) receptors, which could, however, not be simulated with the present neuronal models.

Comments

Neuroscience Letters, Vol. 89, No. 1 (June 1988): 31-35. DOI.

James Buchanan was affiliated with the Karolinska Institute at the time of publication.

Recommended Citation

Grillner, Stan; Buchanan, James T.; and Lansner, A., "Simulation of the Segmental Burst Generating Network for Locomotion in Lamprey" (2014). Biological Sciences Faculty Research and Publications. 186.
https://epublications.marquette.edu/bio_fac/186