Transmitters, Membrane Properties and Network Circuitry in the Control of Locomotion in Lamprey

Authors

Stan Grillner, Karolinska InstituteFollow
Peter Wallén, Karolinska InstituteFollow
Nicholas Dale, Karolinska Institute
Lennart Brodin, Karolinska Institute
James T. Buchanan, Marquette UniversityFollow
Russell H. Hill, Karolinska InstituteFollow

Document Type

Article

Language

eng

Format of Original

8 p.

Publication Date

1-1987

Publisher

Elsevier

Source Publication

Trends in Neurosciences

Source ISSN

0166-2236

Abstract

The lamprey brainstem and spinal cord can be maintained in vitro. It is a simple vertebrate preparation with comparatively few neurones. The neural correlates of different patterns of behaviour can be elicited in this in-vitro preparation. The subject of this review is the neuronal organization underlying locomotion, and, in particular, the role of different types of interneurones and their transmitters and mode of synaptic interaction. Excitatory amino acids, glycine, GABA, 5-HT, tachykinins and CCK have been implied as putative transmitters. The activation of one type of excitatory amino acid receptor, the NMDA receptor, can elicit TTX-resistant pacemaker-like membrane, potential oscillations. 5-HT can exert indirectly a potentiating effect via a depression of the postspike after-hyperpolarization (Ca²⁺-dependent potassium channels).

Comments

Trends in Neuroscience, Vol. 10, No. 1 (January 1987): 34-41. DOI.

James Buchanan was affiliated with the Karolinska Institute at the time of publication.

Recommended Citation

Grillner, Stan; Wallén, Peter; Dale, Nicholas; Brodin, Lennart; Buchanan, James T.; and Hill, Russell H., "Transmitters, Membrane Properties and Network Circuitry in the Control of Locomotion in Lamprey" (1987). Biological Sciences Faculty Research and Publications. 198.
https://epublications.marquette.edu/bio_fac/198