Document Type
Article
Language
eng
Format of Original
9 p.
Publication Date
10-1985
Publisher
Histochemical Society
Source Publication
Journal of Histochemistry and Cytochemistry
Source ISSN
0022-1554
Abstract
Histochemical (M-ATPase) fiber typing was done on extensor digitorum longus, (EDL), soleus (SOL), and diaphragm (DIA) muscles of barrier-reared Fisher 344 rats obtained at four different ages (3, 9, 28, and 30 months) from the colonies of the National Institute of Aging. In the EDL there are no differences in the percent of type I fibers among the four age groups. The percent of type IIa and IIb fibers also showed no difference between the 3 and 30 month age groups. There was no apparent trend for an increase or decrease in the percent of type IIa or IIb fibers between the four age groups. In both the SOL and DIA muscles the percent of type I fibers was greater in the aged than in the young groups. The percent of type IIa fibers was lower in the 30 month group than in the younger groups for both muscles. The percent of type IIb (DIA) and IIc (SOL) fibers did not change between groups. Total fiber number per cross section of muscle showed no change in the EDL over this age range or in the SOL after 9 months of age. These findings bring into question published results that imply that decreasing fiber number and preferential loss of type II (a and b) fibers are typical aging phenomena.
Recommended Citation
Eddinger, Thomas J.; Moss, Richard L.; and Cassens, Robert G., "Fiber Number and Type Composition in Extensor Digitorum Longus, Soleus, and Diaphragm Muscles with Aging in Fisher 344 Rats" (1985). Biological Sciences Faculty Research and Publications. 207.
https://epublications.marquette.edu/bio_fac/207
Comments
Accepted version. Journal of Histochemistry and Cytochemistry, Vol. 33, No. 10 (October 1985): 1033-1041. DOI. © 1985 Histochemical Society. Used with permission.
Thomas Eddinger was affiliated with the University of Wisconsin - Madison at the time of publication.