Modulation of Swimming in the Lamprey, Petromyzon marinus, by Serotonergic and Dopaminergic Drugs

Document Type

Article

Language

eng

Format of Original

4 p.

Publication Date

12-8-1995

Publisher

Elsevier

Source Publication

Neuroscience Letters

Source ISSN

0304-3940

Abstract

The effects of serotonergic and dopaminergic drugs on free swimming behavior in adult sea lampreys (Petromyzon marinus) were investigated using video image analysis. Injections of the serotonin precursor 5-hydroxy-l-tryptophan along with the serotonin reuptake blocker clomipramine into the visceral cavity of lampreys resulted in significant increases in the cycle period of swimming, but had no significant effect on the propagation time of the swim waves down the body (normalized to cycle period), or on the degree of body curvature. Injections of the dopamine agonist apomorphine resulted in significant decreases of cycle period and body curvature with no significant effects on the normalized wave propagation time. The effects on cycle period are consistent with previous findings using serotonin and apomorphine on swimming activity in the isolated spinal cord.

Comments

Neuroscience Letters, Vol. 201, No. 2 (December 8, 1995): 115-118. DOI.

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