Document Type
Article
Language
eng
Format of Original
7 p.
Publication Date
3-2014
Publisher
Spandidos Publications
Source Publication
International Journal of Molecular Medicine
Source ISSN
1107-3756
Original Item ID
doi: 10.3892/ijmm.2013.1604
Abstract
There are statistical data indicating that diabetes is a risk factor for Parkinson's disease (PD). Methylglyoxal (MG), a biologically reactive byproduct of glucose metabolism, the levels of which have been shown to be increase in diabetes, reacts with dopamine to form 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ); this formation may provide further insight into the connection between PD and diabetes. In this study, we investigated the role of ADTIQ in these two diseases to determine in an aim to enhance our understanding of the link between PD and diabetes. To this end, a cell model of hyperglycemia and a rat model of diabetes were established. In the cell model of hyperglycemia, compared with the control group, the elevated glucose levels promoted free hydroxyl radical formation (p
Recommended Citation
Song, De-Wei; Xin, Nian; Xie, Bing-Jie; Li, Yu-Juan; Meng, Ling-Yan; Li, Hong-Mei; Schläppi, Michael; and Deng, Yu-Lin, "Formation of a Salsolinol-like Compound, the Neurotoxin, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, in a Cellular Model of Hyperglycemia and a Rat Model of Diabetes" (2014). Biological Sciences Faculty Research and Publications. 260.
https://epublications.marquette.edu/bio_fac/260
Comments
Published version. International Journal of Molecular Medicine, Vol. 33, No. 3 (March 2014): 736-742. DOI. © 2014 Spandidos Publications. Used with permission.