Document Type

Article

Language

eng

Format of Original

7 p.

Publication Date

3-2014

Publisher

Spandidos Publications

Source Publication

International Journal of Molecular Medicine

Source ISSN

1107-3756

Original Item ID

doi: 10.3892/ijmm.2013.1604

Abstract

There are statistical data indicating that diabetes is a risk factor for Parkinson's disease (PD). Methylglyoxal (MG), a biologically reactive byproduct of glucose metabolism, the levels of which have been shown to be increase in diabetes, reacts with dopamine to form 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ); this formation may provide further insight into the connection between PD and diabetes. In this study, we investigated the role of ADTIQ in these two diseases to determine in an aim to enhance our understanding of the link between PD and diabetes. To this end, a cell model of hyperglycemia and a rat model of diabetes were established. In the cell model of hyperglycemia, compared with the control group, the elevated glucose levels promoted free hydroxyl radical formation (p

Comments

Published version. International Journal of Molecular Medicine, Vol. 33, No. 3 (March 2014): 736-742. DOI. © 2014 Spandidos Publications. Used with permission.

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