Competition of Antigens as Influenced by Spacing of Heterologous Antigen Injections
Format of Original
National Academy of Sciences
Proceedings of the Society for Experimental Biology and Medicine
1) Antibody responses of chickens to single, simultaneous, and spaced injections of bovine serum albumin and human gamma globulin at a dosage level of 40 mg per kilo of body weight are described. 2) Under conditions of simultaneous injection of BSA and HGG antibody responses to both BSA and HGG approximate those of their respective controls. 3) Results of the experiment in which injection of HGG was withheld until 24 hours after that of BSA indicate that antibody response to BSA was significantly reduced. 4) Antibody responses to BSA and HGG in animals in which injection of HGG was delayed for 48 hours approximate the responses of their respective controls. 5) It appears that the character of the antibody response to simultaneous injections of BSA and HGG is regulated by the parameters of dosage level and timing of injections.