Passive Transfer Protection in Traumatic Shock

Document Type

Article

Language

eng

Format of Original

6 p.

Publication Date

2-1968

Publisher

National Academy of Sciences

Source Publication

Proceedings of the Society for Experimental Biology and Medicine

Source ISSN

0037-9727

Abstract

A single iv injection of zymosan (100 mg/ml) lowered the mortality of rats to drum shock 72 hours following injection; similar glucan injections (100 mg/ml) did not affect the shock mortality. Heat-stable complement fixing antibodies were present in serum from zymosan-treated rats; serum from glucan-treated rats had elevated complement titers. Intravenous passive transfer of whole serum from both zymosan- and glucan-injected rats to normal recipient rats lowered the mortality to subsequent drum shock in both groups of recipients; in neither recipient group was there any effect on carbon clearance when compared to saline-injected controls. There appears to be a correlation between serum antibody levels in zymosan-treated rats and passive-transfer shock mortality. The results suggest that in rats injected with zymosan or glucan, immune mechanisms may be concerned with their resistance to subsequent traumatic shock.

Comments

Proceedings of the Society for Experimental Biology and Medicine, Vol. 127, No. 2 (February 1968): 421-426. DOI.

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