Effects of Thyrotoxicosis on Mitochondrial Enzymes of Rat Soleus

Authors

James B. Courtright, Marquette UniversityFollow
Robert H. Fitts, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

1979

Publisher

Georg Thieme Verlag

Source Publication

Hormone and Metabolic Research

Source ISSN

0018-5043

Original Item ID

DOI: 10.1055/s-0028-1092729

Abstract

Cytochrome oxidase, glycerol-3-phosphate dehydrogenase, and succinate dehydrogenase were measured in mitochondrial fractions obtained from rat soleus muscle of control and 8 week T₃ + T₄ treated animals. Under these conditions of prolonged treatment, there is a five-fold increase in the specific activities of both cytochrome oxidase and glycerols-3-phosphate dehydrogenase. Significant increases in total cellular mitochondrial content and enzyme activities were observed in T₃ + T₄ treated animals as compared to controls. These results indicate that thyrotoxicosis can induce selective changes in mitochondrial enzymes in slow twitch red (Type I) muscle fibers.

Comments

Published version. Hormone and Metabolic Research, Vol. 11, No. 4 (1979): 304-306. DOI. © 1979 Georg Thieme Verlag (an imprint of Thieme Publishing). Used with permission.

Recommended Citation

Courtright, James B. and Fitts, Robert H., "Effects of Thyrotoxicosis on Mitochondrial Enzymes of Rat Soleus" (1979). Biological Sciences Faculty Research and Publications. 490.
https://epublications.marquette.edu/bio_fac/490