Document Type
Article
Language
eng
Publication Date
2016
Publisher
Cold Spring Harbor Laboratory Press
Source Publication
Cold Spring Harbor Perspectives in Biology
Source ISSN
1943-0264
Original Item ID
DOI: 10.1101/cshperspect.a028126
Abstract
Propulsive forces generated by cilia and flagella are used in events that are critical for the thriving of diverse eukaryotic organisms in their environments. Despite distinctive strokes and regulations, the majority of them adopt the 9+2 axoneme that is believed to exist in the last eukaryotic common ancestor. Only a few outliers have opted for a simpler format that forsakes the signature radial spokes and the central pair apparatus, although both are unnecessary for force generation or rhythmicity. Extensive evidence has shown that they operate as an integral system for motility control. Recent studies have made remarkable progress on the radial spoke. This review will trace how the new structural, compositional, and evolutional insights pose significant implications on flagella biology and, conversely, ciliopathy.
Recommended Citation
Zhu, Xiaoyan; Liu, Yi; and Yang, Pinfen, "Radial Spokes-A Snapshot of the Motility Regulation, Assembly, and Evolution of Cilia and Flagella" (2016). Biological Sciences Faculty Research and Publications. 534.
https://epublications.marquette.edu/bio_fac/534
Comments
Published version. Cold Harbor Perspectives in Biology (2016). DOI. © 2016 Cold Spring Harbor Laboratory Press. Used with permission.