Document Type

Article

Language

eng

Format of Original

5 p.

Publication Date

6-26-2013

Publisher

Society for Neuroscience

Source Publication

The Journal of Neuroscience

Source ISSN

0270-6474

Original Item ID

doi: 10.1523/JNEUROSCI.0144-13.2013

Abstract

The medial prefrontal cortex (mPFC) plays an important role in memory. By maintaining a working memory buffer, neurons in prelimbic (PL) mPFC may selectively contribute to learning associations between stimuli that are separated in time, as in trace fear conditioning (TFC). Until now, evidence for this bridging role was largely descriptive. Here we used optogenetics to silence neurons in the PL mPFC of rats during learning in TFC. Memory formation was prevented when mPFC was silenced specifically during the interval separating the cue and shock. Our results provide support for a working memory function for these cells and indicate that associating two noncontiguous stimuli requires bridging activity in PL mPFC.

Comments

Published Version. Journal of Neuroscience, Vol. 33, No. 26 (June 2013): 10910-10914. DOI. © Society for Neuroscience 2013. Used with permission.

Marieke Gilmartin was affiliated with the University of Wisconsin - Milwaukee at the time of publication.

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