NR2A- and NR2B-containing NMDA Receptors in the Prelimbic Medial Prefrontal Cortex Differentially Mediate Trace, Delay, and Contextual Fear Conditioning

Authors

Marieke R. Gilmartin, Marquette UniversityFollow
Janine L. Kwapis, University of Wisconsin - Milwaukee
Fred J. Helmstetter, University of Wisconsin - Milwaukee

Document Type

Article

Language

eng

Format of Original

5 p.

Publication Date

6-2013

Publisher

Cold Spring Harbor Laboratory Press

Source Publication

Learning and Memory

Source ISSN

1072-0502

Original Item ID

doi: 10.1101/lm.030510.113

Abstract

Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association. The NR2B subunit confers unique properties to the NMDAR and may differentially regulate these two fear memories. Here we show that NR2A-containing NMDARs mediate trace, delay, and contextual fear memories, but NR2B-containing NMDARs are required only for trace conditioning, consistent with a role for PL mPFC in working memory.

Comments

Published version. Learning and Memory, Vol. 20 (June 2013): 290-294. DOI. © 2013 Cold Spring Harbor Laboratory Press. Used with permission.

Recommended Citation

Gilmartin, Marieke R.; Kwapis, Janine L.; and Helmstetter, Fred J., "NR2A- and NR2B-containing NMDA Receptors in the Prelimbic Medial Prefrontal Cortex Differentially Mediate Trace, Delay, and Contextual Fear Conditioning" (2013). Biomedical Sciences Faculty Research and Publications. 30.
https://epublications.marquette.edu/biomedsci_fac/30