Title

Health Consequences of Circadian Disruption in Humans and Animal Models

Document Type

Contribution to Book

Language

eng

Format of Original

41 p.

Publication Date

2013

Publisher

Elsevier

Source Publication

Chronobiology: Biological Timing in Health and Disease

Source ISSN

9780123969712

Original Item ID

doi: 10.1016/B978-0-12-396971-2.00010-5

Abstract

Daily rhythms in behavior and physiology are programmed by a hierarchical collection of biological clocks located throughout the brain and body, known as the circadian system. Mounting evidence indicates that disruption of circadian regulation is associated with a wide variety of adverse health consequences, including increased risk for premature death, cancer, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive problems, mood disorders, and learning deficits. Here we review the evidence for the pervasive effects of circadian disruption in humans and animal models, drawing from both environmental and genetic studies, and identify questions for future research.

Comments

"Health Consequences of Circadian Disruption in Humans and Animal Models," in Chronobiology: Biological Timing in Health and Disease. Ed. Martha Gillette. Amsterdam: Elsevier (Academic Press), 2013: 283-323. DOI.