Charge Transfer in the Mechanism of Drug Action Involving Quinoxaline Di-N-Oxides
Format of Original
4 p.; 26 cm
Journal of Pharmaceutical Sciences
Original Item ID
doi: 10.1002/jps.2600740427; PubMed Central, PMCID: 3999016
Cyclic voltammetry data were obtained for various 2,3‐disubstituted quinoxaline di‐N‐oxides: dimethyl, bishydroxymethyl, bisacetoxymethyl, bis‐N‐anilinomethyl, and dicarboxaldehyde hydrate. The dimethyl derivative exhibited the most negative E1/2 value, and along with the diol, showed reversible reduction for the first wave. Rationalizations of the E1/2 values are provided. Reasonable correlations exist for the electrochemical data and drug activity. The results support the diiminium theory of drug action.