Mode of Action of Antiprotozoan Agents. Electron Transfer and Oxy Radicals

Authors

James R. Ames, University of Wisconsin - MilwaukeeFollow
Michael D. Ryan, Marquette UniversityFollow
Peter Kovacic, University of Wisconsin - MilwaukeeFollow

Document Type

Article

Language

eng

Format of Original

8 p.

Publication Date

10-19-1987

Publisher

Elsevier

Source Publication

Life Sciences

Source ISSN

0024-3205

Abstract

Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocyles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of −0.3 to −0.9 V. Catalytic production of oxidative pressure from redox cycling involving oxygen is believed to be an important mode of action by the medicinal agents. Literature data contribute support.

Comments

Life Sciences, Vol. 41, No. 16 (October 19 1987): 1895-1902. DOI.

Recommended Citation

Ames, James R.; Ryan, Michael D.; and Kovacic, Peter, "Mode of Action of Antiprotozoan Agents. Electron Transfer and Oxy Radicals" (1987). Chemistry Faculty Research and Publications. 494.
https://epublications.marquette.edu/chem_fac/494