An Integrated Concept of Amebicidal Action: Electron Transfer and Oxy Radicals

Authors

James R. Ames, University of Wisconsin - MilwaukeeFollow
Ulrich Hollstein, University of New Mexico
Anré R. Gagneux, Ciba-Geigy, Switzerland
Michael D. Ryan, Marquette UniversityFollow
Peter Kovacic, University of Wisconsin - MilwaukeeFollow

Document Type

Article

Language

eng

Format of Original

12 p.

Publication Date

1987

Publisher

Elsevier

Source Publication

Free Radical Biology and Medicine

Source ISSN

0891-5849

Abstract

Cyclic voltammetry data were obtained for most of the main categories of antiamebic agents, specifically, quinones, heterocyclic nitro compounds, metal derivatives and chelators, and iminium-type ions. The reductions (our data and literature values) were for the most part reversible, with potentials usually in the favorable range of +0.10 to −0.56 V. The drug effect is believed to result generally from the catalytic production of oxidative stress usually arising from the formation of superoxide via electron transfer. In addition, relevant literature data are provided.

Comments

Free Radical Biology and Medicine, Vol. 3, No. 2 (1987): 85-96. DOI.

Recommended Citation

Ames, James R.; Hollstein, Ulrich; Gagneux, Anré R.; Ryan, Michael D.; and Kovacic, Peter, "An Integrated Concept of Amebicidal Action: Electron Transfer and Oxy Radicals" (1987). Chemistry Faculty Research and Publications. 497.
https://epublications.marquette.edu/chem_fac/497