Newly Identified 'Glutamate Interneurons' and their Role in Locomotion in the Lamprey Spinal Cord

Authors

James T. Buchanan, Marquette UniversityFollow
Stan Grillner, Karolinska InstituteFollow

Document Type

Article

Language

eng

Format of Original

3 p.

Publication Date

4-17-1987

Publisher

American Association for the Advancement of Science

Source Publication

Science

Source ISSN

0036-8075

Abstract

A new class of excitatory premotor interneurons that are important in the generation of locomotion in the lamprey has now been described. In the isolated spinal cord, these neurons act simultaneously with their postsynaptic motoneurons during fictive swimming. They are small and numerous, and they monosynaptically excite both motoneurons and inhibitory premotor interneurons. The excitatory postsynaptic potentials are depressed by an antagonist of excitatory amino acids. These interneurons receive reticulospinal input from the brain stem and polysynaptic input form skin afferents. A model of the network underlying locomotion based on the synaptic interactions of these neurons can now be proposed for the lamprey.

Comments

Science, Vol. 236, No. 4799 (April 17, 1987): 312-314. DOI.

Recommended Citation

Buchanan, James T. and Grillner, Stan, "Newly Identified 'Glutamate Interneurons' and their Role in Locomotion in the Lamprey Spinal Cord" (1987). Biological Sciences Faculty Research and Publications. 184.
https://epublications.marquette.edu/bio_fac/184