Reticulospinal Neurones Activate Excitatory Amino Acid Receptors

Authors

James T. Buchanan, Marquette UniversityFollow
Lennart Brodin, Karolinska Institute
Nicholas Dale, Karolinska Institute
Stan Grillner, Karolinska InstituteFollow

Document Type

Article

Language

eng

Format of Original

5 p.

Publication Date

4-7-1987

Publisher

Elsevier

Source Publication

Brain Research

Source ISSN

0006-8993

Abstract

Paired intracellular recordings were used to study the monosynaptic excitatory postsynaptic potentials (EPSP) in lamprey motoneurones evoked by stimulation of single reticulospinal Müller and Mauthner cells. The chemical component of the synaptic potentials was depressed by bath application of the non-selective excitatory amino acid The N-methyl-d-aspartate (NMDA) antagonists Mg²⁺ and 2-amino-5-phosphonovalerate caused a selective depression of a late component of the EPSP. Thus, fast-conducting reticulospinal neurones appear to release an excitatory amino acid acting at both NMDA and non-NMDA receptors.

Comments

Brain Research, Vol. 408, No. 1-2 (April 7, 1987): 321-325. DOI.

James Buchanan was affiliated with the Karolinska Institute at the time of publication.

Recommended Citation

Buchanan, James T.; Brodin, Lennart; Dale, Nicholas; and Grillner, Stan, "Reticulospinal Neurones Activate Excitatory Amino Acid Receptors" (1987). Biological Sciences Faculty Research and Publications. 221.
https://epublications.marquette.edu/bio_fac/221