Sabeeha S. Merchant, University of California - Los Angeles
Simon E. Prochnik, Joint Genome Institute
Olivier Vallon, Université Paris 6
Elizabeth H. Harris, Duke University
Steven J. Karpowicz, University of California - Los Angeles
George B. Witman, University of Massachusetts Medical School Worcester
Astrid Terry, Joint Genome Institute
Asaf Salamov, Joint Genome Institute
Lillian K. Fritz-Laylin, University of California - Berkeley
Laurence Maréchal-Drouard, Institut de Biologie Moléculaire des Plantes
Wallace F. Marshall, University of California - San Francisco
Liang-Hu Qu, Zhongshan University
David R. Nelson, University of Tennessee
Anton A. Sanderfoot, University of Minnesota
Martin H. Spalding, Iowa State University
Vladimir V. Kapitonov, Genetic Information Research Institute
Qinghu Ren, The Institute for Genomic Research
Patrick Ferris, Salk Institute
Erika Lindquist, Joint Genome Institute
Harris Shapiro, Joint Genome Institute
Susan M. Lucas, Joint Genome Institute
Jane Grimwood, Stanford University School of Medicine
Jeremy Schmutz, Stanford University School of MedicineFollow
Pierre Cardol, University of Liège
Heriberto Cerutti, University of Nebraska-Lincoln
Guillaume Chanfreau, University of California - Los Angeles
Chun-Long Chen, Zhongshan University
Valerie Cognat, Institut de Biologie Moléculaire des Plantes
Martin T. Croft, University of Cambridge
Rachel Dent, University of California - Berkeley
Susan Dutcher, Washington University in St Louis
Emilio Fernández, Universidad de Córdoba
Hideya Fukuzawa, Kyoto University
David González-Ballester, Carnegie Institution
Diego González-Halphen, Universidad Nacional Autónoma de México
Armin Hallmann, University of Bielefeld
Marc Hanikenne, University of Liège
Michael Hippler, University of Münster
William Inwood, University of California - Berkeley
Kamel Jabbari
Ming Kalanon
Richard Kuras
Paul A. Lefebvre, University of Minnesota
Stéphane D. Lemaire, Institut de Biotechnologie des Plantes
Alexey V. Lobanov, University of Nebraska-Lincoln
Martin Lohr, Johannes Gutenberg-Universität
Andrea Manuell, Scripps Research Institute
Iris Meier, Ohio State University
Laurens Mets, University of Chicago
Maria Mittag, Friedrich-Schiller-Universität Jena
Telsa Mittelmeier, University of Arizona
James V. Moroney, Louisiana State University
Jeffrey Moseley, Carnegie Institution
Carolyn Napoli, University of Arizona
Aurora M. Nedelcu, University of New Brunswick
Krishna Niyogi, University of California - Berkeley
Sergey V. Novoselov, University of Nebraska-Lincoln
Ian T. Paulsen, The Institute for Genomic Research
Greg Pazour, University of Massachusetts Medical School Worcester
Saul Purton, University College London
Jean-Philippe Ral, Unité de Glycobiologie Structurale et Fonctionnelle
Diego Mauricio Riaño-Pachón, Institut für Biochemie und Biologie
Wayne Riekhof, National Jewish Medical and Research Center
Linda Rymarquis, University of Delaware
Michael Schroda, Institute of Biology II/Plant Biochemistry
David Stern, Cornell University
James Umen, Salk Institute
Robert Willows, Macquarie University
Nedra Wilson, Oklahoma State University
Sara Lana Zimmer, Cornell University
Jens Allmer, Izmir Ekonomi Universitesi
Janneke Balk, University of Cambridge
Katerina Bisova, Czech Academy of Sciences
Chong-Jian Chen, Zhongshan University
Mark Elias, Charles University
Karla Gendler, University of Arizona
Charles Hauser, St. Edward's University
Mary Rose Lamb, University of Puget Sound
Heidi Ledford, University of California - Berkeley
Joanne C. Long, University of California - Los Angeles
Jun Minagawa, Hokkaido University
M. Dudley Page, University of California - Los Angeles
Junmin Pan, Tsinghua University
Wirulda Pootakham, Carnegie Institution
Sanja Roje, Washington State University
Annkatrin Rose, Appalachian State University
Eric Stahlberg, Ohio State University
Aimee M. Terauchi, University of California - Los Angeles
Pinfen Yang, Marquette UniversityFollow
Steven Ball, Laboratory of Biological Chemistry
Chris Bowler, Stazione Zoologica
Carol L. Dieckmann, University of Arizona
Vadim N. Gladyshev, University of Nebraska-Lincoln
Pamela Green, University of Delaware
Richard Jorgensen, University of Arizona
Stephen Mayfield, Scripps Research Institute
Bernd Mueller-Roeber, Institut für Biochemie und Biologie
Sathish Rajamani, Ohio State University
Richard T. Sayre, Ohio State University
Peter Brokstein, Joint Genome Institute
Inna Dubchak, Joint Genome Institute
David Goodstein, Joint Genome Institute
Leila Hornick, Joint Genome Institute
Y. Wayne Huang, Joint Genome Institute
Jinal Jhaveri, Joint Genome Institute
Yigong Luo, Joint Genome Institute
Diego Martinez, Joint Genome Institute
Wing Chi Abby Ngau, Joint Genome Institute
Bobby Otillar, Joint Genome Institute
Alexander Poliakov, Joint Genome Institute
Aaron Porter, Joint Genome Institute
Lukasz Szajkowski, Joint Genome Institute
Gregory Werner, Joint Genome Institute
Kemin Zhou, Joint Genome Institute
Igor V. Grigoriev, Joint Genome Institute
Daniel S. Rokhsar, Joint Genome Institute
Arthur R. Grossman, Carnegie Institution

Document Type




Format of Original

6 p.

Publication Date



American Association for the Advancement of Science

Source Publication


Source ISSN



Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.


Accepted version. Science, Vol. 318, No. 5848 (October 2007): 245-250. DOI. © 2007 American Association for the Advancement of Science. Used with permission.

Included in

Biology Commons