Response of Rabbits to Pyrogen in a Helox Environment
Journal of Thermal Biology
1.|The effectiveness of a gas environment consisting of 80% helium and 20% oxygen (Helox) in reducing a rabbit's fever due to an i.v. injection of endotoxin was found to be dependent on the amount of pyrogen injected.
2.|When a relatively large dose of pyrogen was injected, the helox environment used in these experiments reduced the mean maximum temperature reached during the fever from 41.5 to 40.5°C, but the helox did not significantly alter the change in temperature from baseline levels prior to the injection (a 1.4°C increase in air and a 1.1°C increase in helox).
3.|When a relatively low dose of pyrogen was injected, the helox environment increased the change in temperature from baseline at peak fever, but did not produce a significant change in the actual temperatures attained during the fever.
Vaughn, Linda K.; Veale, W. L.; and Cooper, K. E., "Response of Rabbits to Pyrogen in a Helox Environment" (1980). Biological Sciences Faculty Research and Publications. 667.