Response of Rabbits to Pyrogen in a Helox Environment

Document Type

Article

Language

eng

Publication Date

10-1980

Publisher

Elsevier

Source Publication

Journal of Thermal Biology

Source ISSN

0306-4565

Abstract

1.|The effectiveness of a gas environment consisting of 80% helium and 20% oxygen (Helox) in reducing a rabbit's fever due to an i.v. injection of endotoxin was found to be dependent on the amount of pyrogen injected.

2.|When a relatively large dose of pyrogen was injected, the helox environment used in these experiments reduced the mean maximum temperature reached during the fever from 41.5 to 40.5°C, but the helox did not significantly alter the change in temperature from baseline levels prior to the injection (a 1.4°C increase in air and a 1.1°C increase in helox).

3.|When a relatively low dose of pyrogen was injected, the helox environment increased the change in temperature from baseline at peak fever, but did not produce a significant change in the actual temperatures attained during the fever.

Comments

Journal of Thermal Biology, Vol. 5, No. 4 (October 1980): 203-206. DOI.

Linda K. Vaugh was affiliated with the University of Calgary at the time of publication.

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