Pulmonary Disposition of Lipophilic Amine Compounds in the Isolated Perfused Rabbit Lung

Authors

Said H. Audi, Marquette UniversityFollow
Christopher A. Dawson, Medical College of Wisconsin
John H. Linehan, Marquette University
Gary S. Krenz, Marquette UniversityFollow
S. B. Ahlf, Zablocki Veterans Affairs Medical Center
David L. Roerig, Medical College of Wisconsin

Document Type

Article

Language

eng

Format of Original

15 p.

Publication Date

2-1998

Publisher

American Physiological Society

Source Publication

Journal of Applied Physiology

Source ISSN

0021-8987

Original Item ID

DOI: 10.1152/jappl.1998.84.2.516

Abstract

We measured the pulmonary venous concentration vs. time curves for [³H]alfentanil, [¹⁴C]lidocaine, and [³H]codeine after the bolus injection of each of these lipophilic amine compounds (LAC) and a vascular-reference indicator (fluorescein isothiocyanate-dextran) into the pulmonary artery of isolated perfused rabbit lungs. A range of flows and perfusate albumin concentrations was studied. To evaluate the information content of the data, we developed a kinetic model describing the pulmonary disposition of these LAC that was based on indicator dilution theory, and we sought a robust approach for interpreting the estimated model parameters. We found that the distribution of the kinetic model rate constants of the lipophilic amine-tissue interactions can be described by α̃,H̃, and , where α̃ is a measure of the capacity of the rapidly equilibrating interactions between the lipophilic amine and the tissue; H̃ is a measure of the equilibrium capacity of the slowly equilibrating interactions between the lipophilic amine and the tissue; and is the mean sojourn time. The values of α̃, H̃, and were 0.8 ± 0.1 (SE), 0.6 ± 0.1, and 1.6 ± 0.5 s; 1.9 ± 0.1, 5.3 ± 0.4, and 5.6 ± 0.5 s; and 1.1 ± 0.1, 9.8 ± 0.4, and 4.7 ± 0.2 s for alfentanil, lidocaine, and codeine, respectively. These values for α̃, H̃, and reveal the relative dominance of the slowly equilibrating interactions for lidocaine and codeine in comparison with alfentanil. This approach to data analysis may have utility for the potential use of LAC to reveal and to quantify changes in lung tissue composition associated with lung disease.

Comments

Journal of Applied Psychology, Vol. 84, No.2 (February 1998): 516-530. DOI.

Recommended Citation

Audi, Said H.; Dawson, Christopher A.; Linehan, John H.; Krenz, Gary S.; Ahlf, S. B.; and Roerig, David L., "Pulmonary Disposition of Lipophilic Amine Compounds in the Isolated Perfused Rabbit Lung" (1998). Biomedical Engineering Faculty Research and Publications. 12.
https://epublications.marquette.edu/bioengin_fac/12