Chronic Hypoxia Effects Active Tone Differently in the Pulmonary Arteries of Brown-Norway, Spraque-Dawley, and Fawn-Hooded Rats

Authors

Robert C. Molthen, Marquette UniversityFollow
Steven Thomas Haworth, Medical College of WisconsinFollow
John B. Gordon, Medical College of WisconsinFollow
Gary S. Krenz, Marquette UniversityFollow
Anne V. Clough, Marquette UniversityFollow

Document Type

Article

Language

eng

Format of Original

1 p.

Publication Date

2005

Publisher

Federation of the American Society of Experimental Biology

Source Publication

FASEB Journal

Source ISSN

0892-6638

Abstract

The amount of active tone in the pulmonary arteries can have a significant impact on the hemodynamic load placed on the right heart, in particular in the presence of chronic alveolar hypoxia. We determine the amount of active tone in the pulmonary vasculature of 3 strains of rats after 21-day exposure to either 10% oxygen or room air, by performing hemodynamic measurements in isolated lungs before and after adding 6 mg of papaverine (Papav) to the circulating perfusate. Pulmonary vein and airway pressure were maintained at 0 mmHg and 6 mmHg, respectively, and pulmonary artery pressure (PAP) was measured at flow rates of 40, 30, 20, 10, 5, and 0 ml/min. At a flow rate of 40ml/min, PAP was significantly different (P

Comments

FASEB Journal, Vol. 19 (2005): A913. Publisher Link.

Recommended Citation

Molthen, Robert C.; Haworth, Steven Thomas; Gordon, John B.; Krenz, Gary S.; and Clough, Anne V., "Chronic Hypoxia Effects Active Tone Differently in the Pulmonary Arteries of Brown-Norway, Spraque-Dawley, and Fawn-Hooded Rats" (2005). Biomedical Engineering Faculty Research and Publications. 197.
https://epublications.marquette.edu/bioengin_fac/197