Chronic Hypoxia Effects Active Tone Differently in the Pulmonary Arteries of Brown-Norway, Spraque-Dawley, and Fawn-Hooded Rats
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Federation of the American Society of Experimental Biology
The amount of active tone in the pulmonary arteries can have a significant impact on the hemodynamic load placed on the right heart, in particular in the presence of chronic alveolar hypoxia. We determine the amount of active tone in the pulmonary vasculature of 3 strains of rats after 21-day exposure to either 10% oxygen or room air, by performing hemodynamic measurements in isolated lungs before and after adding 6 mg of papaverine (Papav) to the circulating perfusate. Pulmonary vein and airway pressure were maintained at 0 mmHg and 6 mmHg, respectively, and pulmonary artery pressure (PAP) was measured at flow rates of 40, 30, 20, 10, 5, and 0 ml/min. At a flow rate of 40ml/min, PAP was significantly different (P
Molthen, Robert C.; Haworth, Steven Thomas; Gordon, John B.; Krenz, Gary S.; and Clough, Anne V., "Chronic Hypoxia Effects Active Tone Differently in the Pulmonary Arteries of Brown-Norway, Spraque-Dawley, and Fawn-Hooded Rats" (2005). Biomedical Engineering Faculty Research and Publications. 197.
FASEB Journal, Vol. 19 (2005): A913. Publisher Link.