Document Type
Article
Language
eng
Format of Original
5 p.
Publication Date
12-2010
Publisher
Elsevier
Source Publication
Progress in Pediatric Cardiology
Source ISSN
1058-9813
Original Item ID
doi: 10.1016/j.ppedcard.2010.09.006
Abstract
Coarctation of the aorta (CoA) is often considered a relatively simple disease, but long-term outcomes suggest otherwise as life expectancies are decades less than in the average population and substantial morbidity often exists. What follows is an expanded version of collective work conducted by the authors' and numerous collaborators that was presented at the 1st International Conference on Computational Simulation in Congenital Heart Disease pertaining to recent advances for CoA. The work begins by focusing on what is known about blood flow, pressure and indices of wall shear stress (WSS) in patients with normal vascular anatomy from both clinical imaging and the use of computational fluid dynamics (CFD) techniques. Hemodynamic alterations observed in CFD studies from untreated CoA patients and those undergoing surgical or interventional treatment are subsequently discussed. The impact of surgical approach, stent design and valve morphology are also presented for these patient populations. Finally, recent work from a representative experimental animal model of CoA that may offer insight into proposed mechanisms of long-term morbidity in CoA is presented.
Recommended Citation
LaDisa, John F.; Taylor, Charles A.; and Feinstein, Jeffrey A., "Aortic Coarctation: Recent Developments in Experimental and Computational Methods to Assess Treatments for this Simple Condition" (2010). Biomedical Engineering Faculty Research and Publications. 36.
https://epublications.marquette.edu/bioengin_fac/36
Comments
Accepted version. Progress in Pediatric Cardiology, Volume 30, No. 1-2 (December 2010), DOI. © 2010 Elsevier. Used with permission.