Document Type
Article
Language
eng
Format of Original
12 p.
Publication Date
1-2016
Publisher
Wiley
Source Publication
Journal of Magnetic Resonance Imaging
Source ISSN
1053-1807
Original Item ID
DOI: 10.1002/jmri.24964; PubMed Central: PMID: 26094789
Abstract
Background: The purpose of this study was to determine whether DTI changes in the brain induced by a thoracic spinal cord injury are sensitive to varying severity of spinal contusion in rats.
Methods: A control, mild, moderate, or severe contusion injury was administered over the eighth thoracic vertebral level in 32 Sprague-Dawley rats. At 11 weeks postinjury, ex vivo DTI of the brain was performed on a 9.4T Bruker scanner using a pulsed gradient spin-echo sequence.
Results: Mean water diffusion in the internal capsule regions of the brain and pyramid locations of the brainstem were correlated with motor function (r2 = 0.55). Additionally, there were significant differences between injury severity groups for mean diffusivity and fractional anisotropy at regions associated with the corticospinal tract (P = 0.05).
Conclusion: These results indicate that DTI is sensitive to changes in brain tissue as a consequence of thoracic SCI.
Recommended Citation
Jirjis, Michael B.; Vedantam, Aditya; Budde, Matthew D.; Kalinosky, Benjamin; and Kurpad, Shekar N., "Severity of Spinal Cord Injury Influences Diffusion Tensor Imaging of the Brain" (2016). Biomedical Engineering Faculty Research and Publications. 406.
https://epublications.marquette.edu/bioengin_fac/406
Comments
Accepted version. Journal of Magnetic Resonance Imaging, Vol. 43, No. 1 (January 2016): 63-74. DOI.
This is the peer reviewed version of the following article: "Severity of Spinal Cord Injury Influences Diffusion Tensor Imaging of the Brain." Journal of Magnetic Resonance Imaging, Vol. 43, No. 1 (January 2016): 63-74., which has been published in final form at DOI. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving'.