Format of Original
Journal of Magnetic Resonance Imaging
Original Item ID
DOI: 10.1002/jmri.24964; PubMed Central: PMID: 26094789
Background: The purpose of this study was to determine whether DTI changes in the brain induced by a thoracic spinal cord injury are sensitive to varying severity of spinal contusion in rats.
Methods: A control, mild, moderate, or severe contusion injury was administered over the eighth thoracic vertebral level in 32 Sprague-Dawley rats. At 11 weeks postinjury, ex vivo DTI of the brain was performed on a 9.4T Bruker scanner using a pulsed gradient spin-echo sequence.
Results: Mean water diffusion in the internal capsule regions of the brain and pyramid locations of the brainstem were correlated with motor function (r2 = 0.55). Additionally, there were significant differences between injury severity groups for mean diffusivity and fractional anisotropy at regions associated with the corticospinal tract (P = 0.05).
Conclusion: These results indicate that DTI is sensitive to changes in brain tissue as a consequence of thoracic SCI.
Jirjis, Michael B.; Vedantam, Aditya; Budde, Matthew D.; Kalinosky, Benjamin; and Kurpad, Shekar N., "Severity of Spinal Cord Injury Influences Diffusion Tensor Imaging of the Brain" (2016). Biomedical Engineering Faculty Research and Publications. 406.
Accepted version. Journal of Magnetic Resonance Imaging, Vol. 43, No. 1 (January 2016): 63-74. DOI.
This is the peer reviewed version of the following article: "Severity of Spinal Cord Injury Influences Diffusion Tensor Imaging of the Brain." Journal of Magnetic Resonance Imaging, Vol. 43, No. 1 (January 2016): 63-74., which has been published in final form at DOI. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving'.