Document Type
Article
Language
eng
Publication Date
2015
Publisher
F1000Research
Source Publication
F1000Research
Source ISSN
2046-1402
Abstract
Osteogenesis imperfecta (OI) is an uncommon genetic bone disease associated with brittle bones and fractures in children and adults. Although OI is most commonly associated with mutations of the genes for type I collagen, many other genes (some associated with type I collagen processing) have now been identified. The genetics of OI and advances in our understanding of the biomechanical properties of OI bone are reviewed in this article. Treatment includes physiotherapy, fall prevention, and sometimes orthopedic procedures. In this brief review, we will also discuss current understanding of pharmacologic therapies for treatment of OI.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Shaker, Joseph L.; Albert, Carolyne; Fritz, Jessica M.; and Harris, Gerald F., "Recent Developments in Osteogenesis Imperfecta" (2015). Biomedical Engineering Faculty Research and Publications. 431.
https://epublications.marquette.edu/bioengin_fac/431
Comments
Published version. F1000Reserach, (2015). DOI. © 2015 Shaker JL et al. Used with permission.