Thermodynamically-Constrained Computational Model of Lung Mitochondrial Bioenergetics

Authors

Xiao Zhang, Marquette UniversityFollow
Ranjan K. Dash, Medical College of Wisconsin
Anne V. Clough, Marquette UniversityFollow
Elizabeth R. Jacobs, Medical College of WisconsinFollow
Said H. Audi, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

2015

Publisher

Biomedical Engineering Society

Source Publication

2015 Biomedical Engineering Society Annual Meeting

Abstract

Acute lung injury (ALI), characterized by rapidly progressing hypoxic lung failure, is one of the most frequent causes of admission to medical intensive care units [1]. Studies have suggested that mitochondrial dysfunction plays a key role in the pathogenesis of ALI [2]. Thus, the objective of this study is to develop and validate a thermodynamically-constrained computational model of lung mitochondrial bioenergetics.

Comments

Published as a part of the 2015 Biomedical Engineering Society Annual Meeting. Publisher Link.

Recommended Citation

Zhang, Xiao; Dash, Ranjan K.; Clough, Anne V.; Jacobs, Elizabeth R.; and Audi, Said H., "Thermodynamically-Constrained Computational Model of Lung Mitochondrial Bioenergetics" (2015). Biomedical Engineering Faculty Research and Publications. 479.
https://epublications.marquette.edu/bioengin_fac/479