Thermodynamically-Constrained Computational Model of Lung Mitochondrial Bioenergetics
Biomedical Engineering Society
2015 Biomedical Engineering Society Annual Meeting
Acute lung injury (ALI), characterized by rapidly progressing hypoxic lung failure, is one of the most frequent causes of admission to medical intensive care units . Studies have suggested that mitochondrial dysfunction plays a key role in the pathogenesis of ALI . Thus, the objective of this study is to develop and validate a thermodynamically-constrained computational model of lung mitochondrial bioenergetics.