Bone Properties by Nanoindentation in Mild and Severe Osteogenesis Imperfecta

Authors

Carolyne Albert, Marquette UniversityFollow
John Jameson, Marquette UniversityFollow
Jeffrey M. Toth, Marquette UniversityFollow
Peter Smith, Shriners Hospitals for Children
Gerald F. Harris, Marquette UniversityFollow

Document Type

Article

Language

eng

Format of Original

7 p.

Publication Date

1-2013

Publisher

Elsevier

Source Publication

Clinical Biomechanics

Source ISSN

0268-0033

Original Item ID

doi: 10.1016/j.clinbiomech.2012.10.003

Abstract

Background

Osteogenesis imperfecta is a heterogeneous genetic disorder characterized by bone fragility. Previous research suggests that impaired collagen network and abnormal mineralization affect bone tissue properties, however, little data is yet available to describe bone material properties in individuals with this disorder. Bone material properties have not been characterized in individuals with the most common form of osteogenesis imperfecta, type I.

Methods

Bone tissue elastic modulus and hardness were measured by nanoindentation in eleven osteotomy specimens that were harvested from children with osteogenesis imperfecta during routine surgeries. These properties were compared between osteogenesis imperfecta types I (mild, n = 6) and III (severe, n = 5), as well as between interstitial and osteonal microstructural regions using linear mixed model analysis.

Findings

Disease severity type had a small but statistically significant effect on modulus (7%, P = 0.02) and hardness (8%, P < 0.01). Individuals with osteogenesis imperfecta type I had higher modulus and hardness than did those with type III. Overall, mean modulus and hardness values were 13% greater in interstitial lamellar bone regions than in osteonal regions (P < 0.001).

Interpretation

The current study presents the first dataset describing bone material properties in individuals with the most common form of osteogenesis imperfecta, i.e., type I. Results indicate that intrinsic bone tissue properties are affected by phenotype. Knowledge of the material properties of bones in osteogenesis imperfecta will contribute to the ability to develop models to assist in predicting fracture risk.

Comments

Accepted version. Clinical Biomechanics, Vol. 20, No. 1 (January 2013): 110-116. DOI. © 2013 Elsevier. Used with permission.

Recommended Citation

Albert, Carolyne; Jameson, John; Toth, Jeffrey M.; Smith, Peter; and Harris, Gerald F., "Bone Properties by Nanoindentation in Mild and Severe Osteogenesis Imperfecta" (2013). Biomedical Engineering Faculty Research and Publications. 56.
https://epublications.marquette.edu/bioengin_fac/56