Intergrader Agreement of Foveal Cone Topography Measured Using Adaptive Optics scanning Light Ophthalmoscopy

Authors

Niamh Wynne, Medical College of Wisconsin
Jenna A. Cava, Medical College of Wisconsin
Mina Gaffney, Marquette University
Heather Heitkotter, Medical College of Wisconsin
Abigail Scheidt, Medical College of Wisconsin
Jenny L. Reiniger, University of Bonn, Germany
Jenna Grieshop, Marquette University
Kai Yang, Medical College of Wisconsin
Wolf M. Harmening, University of Bonn, Germany
Robert F. Cooper, Marquette UniversityFollow
Joseph Carroll, Medical College of WisconsinFollow

Document Type

Article

Publication Date

8-2022

Publisher

Optical Society of America

Source Publication

Biomedical Optics Express

Source ISSN

2156-7085

Original Item ID

DOI: 10.1364/BOE.460821

Abstract

The foveal cone mosaic can be directly visualized using adaptive optics scanning light ophthalmoscopy (AOSLO). Previous studies in individuals with normal vision report wide variability in the topography of the foveal cone mosaic, especially the value of peak cone density (PCD). While these studies often involve a human grader, there have been no studies examining intergrader reproducibility of foveal cone mosaic metrics. Here we re-analyzed published AOSLO foveal cone images from 44 individuals to assess the relationship between the cone density centroid (CDC) location and the location of PCD. Across 5 graders with variable experience, we found a measurement error of 11.7% in PCD estimates and higher intergrader reproducibility of CDC location compared to PCD location (p < 0.0001). These estimates of measurement error can be used in future studies of the foveal cone mosaic, and our results support use of the CDC location as a more reproducible anchor for cross-modality analyses.

Comments

Accepted version. Biomedics Optics Express, Vol. 13, No. 8 (August 2022): 4445-4454. DOI. © 2022 Optical Society of America. Used with permission.

Recommended Citation

Wynne, Niamh; Cava, Jenna A.; Gaffney, Mina; Heitkotter, Heather; Scheidt, Abigail; Reiniger, Jenny L.; Grieshop, Jenna; Yang, Kai; Harmening, Wolf M.; Cooper, Robert F.; and Carroll, Joseph, "Intergrader Agreement of Foveal Cone Topography Measured Using Adaptive Optics scanning Light Ophthalmoscopy" (2022). Biomedical Engineering Faculty Research and Publications. 656.
https://epublications.marquette.edu/bioengin_fac/656