Document Type
Article
Publication Date
7-2025
Publisher
Taylor & Francis
Source Publication
International Journal of Radiation Biology
Source ISSN
0955-3002
Abstract
Purpose: Dr. Richard Hill performed pioneering work in the field of radiation-induced normal tissue injury to the lung including noninvasive imaging studies aimed at identifying imaging biomarkers of radiation-induced lung injury (RILI). RILI is a life-threatening toxicity of radiation exposure relevant to both cancer patients undergoing thoracic radiation therapy (RT) and victims of accidental radiation exposure. The ability to detect RILI noninvasively has the potential to guide treatment planning for RT and, in the case of victims of acute radiation exposures, inform the decision to start mitigative therapies. As part of this special issue of IJRB honoring Dr. Hill’s many contributions to the field of radiation biology, this article reviews current advances in noninvasive imaging of RILI including computed tomography (CT), magnetic resonance (MR), hyperpolarized MR, nuclear medicine (PET and SPECT), and optical imaging with near-infrared (NIR) probes. Conclusion: The imaging modalities reviewed have potential to not only provide early identification of RILI but may also provide mechanistic insights into the progression of RILI via noninvasive detection of characteristic RILI mechanisms including: inflammation, vascular damage, cell death, oxidative stress, and fibrosis.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Nissen, Austen; Audi, Said H.; Clough, Anne V.; Fish, Brian; Joshi, Amit; Medhora, Meetha; Sidabras, Jason Walter; and Himburg, Heather A., "Advances in Noninvasive Imaging for Detecting Radiation-Induced Lung Injury (RILI)" (2025). Biomedical Engineering Faculty Research and Publications. 688.
https://epublications.marquette.edu/bioengin_fac/688
Comments
Published version. International Journal of Radiation Biology, Vol. 20 (July 2025): 12431-12465. DOI. © 2025 The Author(s). Published with license by Taylor & Francis Group, LLC and permission has been granted for this version to appear in e-Publications@Marquette. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.