Magnetic Capture of Autologous Mesenchymal Stem Cells Promotes the Rapid Endothelialization of Peripheral Venous Stents in Rabbits

Document Type

Article

Publication Date

7-2025

Publisher

Elsevier

Source Publication

Acta Biomaterialia

Source ISSN

1742-7061

Original Item ID

DOI: 10.1016/j.actbio.2025.07.017

Abstract

The rapid development of an endothelium over venous stents is associated with improved clinical outcomes. In this study, we investigate an approach to rapidly endothelialize venous stents using magnetic cell capture. Autologous mesenchymal stem cells were generated from rabbit adipose tissue and labeled with superparamagnetic iron oxide nanoparticles. Non-magnetic control and magnetic stents were deployed in the opposite external iliac veins of rabbits. The cells were delivered into the stent lumens in the presence of external magnets. Magnetic cell capture and retention, rate of endothelization, and stenosis were evaluated histologically. We found that the cells were capable of being magnetically captured by and adhering to the magnetic stents. Their magnetic capture facilitated the development of an endothelium over the magnetic stents within 3 days. In contrast, no magnetic cell capture was observed on the control stents, and the control stents were completely bare after 3 days. We found no significant difference in stenosis between the control and magnetic stents after 30 days. In conclusion, we demonstrated that autologous adipose derived mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles are capable of being magnetically captured to the surface of magnetic stents, improving the rate of endothelialization in a rabbit iliac vein model.

Comments

Acta Biomaterialia, Vol. 211 (July 2025): 188-203. DOI. See Article for Full Author List.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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