Document Type
Article
Language
eng
Format of Original
7 p.
Publication Date
2008
Publisher
American Heart Association
Source Publication
Arteriosclerois, Thrombosis, and Vascular Biology
Source ISSN
1079-5642
Original Item ID
doi: 10.1161/ATVBAHA.108.172270
Abstract
Objective—Atherosclerosis is a vascular disease that involves lesion formation at sites of disturbed flow under the influence of genetic and environmental factors. Endothelial expression of adhesion molecules that enable infiltration of immune cells is important for lesion development. Platelet/endothelial cell adhesion molecule-1 (PECAM-1; CD31) is an adhesion and signaling receptor expressed by many cells involved in atherosclerotic lesion development. PECAM-1 transduces signals required for proinflammatory adhesion molecule expression at atherosusceptible sites; thus, it is predicted to be proatherosclerotic. PECAM-1 also inhibits inflammatory responses, on which basis it is predicted to be atheroprotective.
Methods and Results—We evaluated herein the effect of PECAM-1 deficiency on development of atherosclerosis in LDL receptor– deficient mice. We found that PECAM-1 has both proatherosclerotic and atheroprotective effects, but that the former dominate in the inner curvature of the aortic arch whereas the latter dominate in the aortic sinus, branching arteries, and descending aorta. Endothelial cell expression of PECAM-1 was sufficient for its atheroprotective effects in the aortic sinus but not in the descending aorta, where the atheroprotective effects of PECAM-1 also required its expression on bone marrow–derived cells.
Conclusion—We conclude that PECAM-1 influences initiation and progression of atherosclerosis both positively and negatively, and that it does so in a site-specific manner. (Arterioscler Thromb Vasc Biol. 2008;28:1996-2002)
Recommended Citation
Arora, Shikha; Boylan, Brian; Goel, Reema; Schrank, Benjamin R.; Fleming, Barbara; Fleming, Rose Ann; Mirura, Hiroto; Newman, Peter J.; Molthen, Robert C.; and Newman, Debra K., "Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor-Deficient Mice" (2008). Biomedical Engineering Faculty Research and Publications. 99.
https://epublications.marquette.edu/bioengin_fac/99
Comments
Accepted version. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 28, No. 11 (July 2008): 1996-2002. DOI. © 2008 American Heart Association, Inc. Used with permission.