Document Type

Article

Language

eng

Publication Date

2-2012

Publisher

Future Science

Source Publication

Future Medicinal Chemistry

Source ISSN

1756-8919

Original Item ID

DOI: 10.4155/fmc.11.166

Abstract

Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine. The pharmacological profile of l-THP, which includes antagonism of dopamine D1 and D2 receptors and actions at dopamine D3, α adrenergic and serotonin receptors, suggests that it may have utility for treating cocaine addiction. In this review, we provide an overview of the pharmacological properties of l-THP and the evidence supporting its development as an anti-addiction medication. The results of preclinical work demonstrating that l-THP attenuates cocaine’s reinforcing/rewarding effects and reinstatement in rat models of cocaine relapse are summarized, and the outcomes of studies demonstrating efficacy in human addicts are described. Finally, an overview of the safety profile of l-THP is provided and challenges associated with US FDA approval of l-THP are discussed.

Comments

Accepted version. Future Medicinal Chemistry, Vol. 4, No. 2 (February 2012): 177-186. DOI. © 2012 Future Science. Used with permission.

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