The Effect of Temperature on the Inhibition of Trout, Carp and Human Red Cell Hexokinase by Triethyltin Bromide

Document Type

Article

Publication Date

1981

Publisher

Elsevier

Source Publication

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

Source ISSN

1532-0456

Original Item ID

DOI: 10.1016/0306-4492(81)90060-5

Abstract

1. At temperatures below 20°C, brook and rainbow trout red cell hexokinases demonstrate sensitivity to the inhibitory effects of triethyltin bromide.

2. When the incubation temperature was raised to above 25°C, carp and human red cell enzymes were affected.

3. Arrhenius plots indicated that the ΔH∗ of the reaction was about 11 kcal for the trout enzymes and 40 kcal for the carp and human enzymes.

4. The differential temperature sensitivity of the trout and human enzymes to triethyltin is correlated with the temperature sensitivity of the corresponding red cells toward the hemolytic effect of the reagent.

Comments

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, Vol. 70, No. 2 (1981): 261-264. DOI.

Kevin Siebenlist was affiliated with the Medical College of Wisconsin at the time of publication.

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