Evidence for Covalent Linkage Between Some Plasma α2-Antiplasmin Molecules and Aα Chains of Circulating Fibrinogen

Authors

Michael W. Mosesson, Blood Center of WisconsinFollow
Trudy Holyst, Blood Research InstituteFollow
Irene Hernandez, Blood Research InstituteFollow
Kevin R. Siebenlist, Marquette UniversityFollow

Document Type

Article

Publication Date

5-2013

Publisher

Wiley

Source Publication

Journal of Thrombosis and Haemostasis

Source ISSN

1538-7933

Original Item ID

DOI: 10.1111/jth.12193

Abstract

Plasma alpha₂-antiplasmin (α₂AP) is a single-chain serine protease inhibitor acting mainly through the fibrinolytic system. Its physiological importance is underscored by the observation that homozygous α₂AP deficiency results in a severe hemorrhagic disorder due to rapid fibrin clot lysis (hyperfibrinolysis).

Comments

Accepted version. Journal of Thrombosis and Haemostasis, Vol. 11, No. 5 (May 2013): 995-998. DOI. © 2013 Wiley. Used with permission.

Recommended Citation

Mosesson, Michael W.; Holyst, Trudy; Hernandez, Irene; and Siebenlist, Kevin R., "Evidence for Covalent Linkage Between Some Plasma α2-Antiplasmin Molecules and Aα Chains of Circulating Fibrinogen" (2013). Biomedical Sciences Faculty Research and Publications. 218.
https://epublications.marquette.edu/biomedsci_fac/218