Inhibition of Red Cell and Yeast Hexokinase by Triethyltin Bromide [(C₂H₅)₃SnBr]

Authors

Kevin R. Siebenlist, Marquette UniversityFollow
Fumito Taketa, Milwaukee Blood Center

Document Type

Article

Publication Date

7-1980

Publisher

Elsevier

Source Publication

Biochemical and Biophysical Research Communications

Source ISSN

0006-291X

Original Item ID

DOI: 10.1016/0006-291X(80)90851-7

Abstract

Triethyltin bromide was found to be a selective inhibitor of red cell hexokinase. When intact red cell suspensions were exposed to the reagent (0.025–0.5 mM), inhibition of hexokinase occurred without any hemolysis and without effects on the activity of other glycolytic enzymes. Yeast hexokinase was also inhibited by triethyltin. The red cell and yeast hexokinases were protected against inhibition by triethyltin when the sugar substrates of the enzymes were included in the incubation mixture. This work identifies hexokinase as another among a limited number of proteins that are known to interact with triethyltin.

Comments

Biochemical and Biophysical Research Communications, Vol. 95, No. 2 (July 1980): 758-764. DOI.

Recommended Citation

Siebenlist, Kevin R. and Taketa, Fumito, "Inhibition of Red Cell and Yeast Hexokinase by Triethyltin Bromide [(C₂H₅)₃SnBr]" (1980). Biomedical Sciences Faculty Research and Publications. 221.
https://epublications.marquette.edu/biomedsci_fac/221