Strain-Dependent Variability in Nitrous Oxide Withdrawal Seizure Frequency

Authors

Linda K. Vaughn, Marquette UniversityFollow
Ronald J. Pruhs, Marquette UniversityFollow

Document Type

Article

Language

eng

Format of Original

6 p.

Publication Date

8-1995

Publisher

Elsevier

Source Publication

Life Sciences

Source ISSN

0024-3205

Original Item ID

doi: 10.1016/0024-3205(95)02057-P

Abstract

Exposure to nitrous oxide produces handling induced convulsions following withdrawal in mice. Since strain differences in responsiveness to the antinociceptive potency of N₂O have been found, we examined whether there were differences in susceptibility to N₂O withdrawal seizures. Significant differences were found between mouse strains, varying between 100% and 0% of mice exhibiting withdrawal seizures. There was a lack of correlation between the sensitivity of the mouse strains to N₂O-induced analgesia and N₂O withdrawal seizures, suggesting different mechanisms of action.

Comments

Life Sciences, Vol. 57, No. 11 (August 1995): 1125-1130. DOI.

Recommended Citation

Vaughn, Linda K. and Pruhs, Ronald J., "Strain-Dependent Variability in Nitrous Oxide Withdrawal Seizure Frequency" (1995). Biomedical Sciences Faculty Research and Publications. 75.
https://epublications.marquette.edu/biomedsci_fac/75