The Effect of Venous Blood Stream Cooling on Survival of Bacterially Infected Rabbits

Authors

Linda K. Vaughn, Marquette UniversityFollow
W. L. Veale, University of Calgary Faculty of Medicine
K. E. Cooper, University of Calgary Faculty of Medicine

Document Type

Article

Language

eng

Format of Original

3 p.

Publication Date

8-1987

Publisher

Springer

Source Publication

Pflügers Archiv: European Journal of Physiology

Source ISSN

0031-6768

Original Item ID

doi: 10.1007/BF00584665

Abstract

The effect of physical cooling on the mortality rate of rabbits infected with Pasteurella multocida was investigated. Rabbits were colled for 48 hours after bacterial injection by passing cold fluid through small hollow metal cuffs which had been surgically implanted around the abdominal vena cavae of rabbits. The average body temperatures of the rabbits during the 24-hour period after the intravenous injection of live Pasteurella multocida was 40.92±0.20°C in control rabbits and 38.98±0.71°C in cooled rabbits. 90% of physically cooled rabbits survived compared with 46% of control rabbits 48 hours after bacterial injection, suggesting that thermoregulatory effector mechanisms involved in cold defense may enhance survival.

Comments

Pflügers Archiv: European Journal of Physiology, Vol. 409, No. 6 (August 1987): 635-637. DOI.

Recommended Citation

Vaughn, Linda K.; Veale, W. L.; and Cooper, K. E., "The Effect of Venous Blood Stream Cooling on Survival of Bacterially Infected Rabbits" (1987). Biomedical Sciences Faculty Research and Publications. 78.
https://epublications.marquette.edu/biomedsci_fac/78