Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines

Authors

Pandula T. Kirinde ArachchigeFollow
Chae S. Yi, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

4-2019

Publisher

American Chemical Society

Source Publication

Organic Letters

Source ISSN

1523-7060

Abstract

The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.

Comments

Accepted version. Organic Letters, Vol. 21, No. 9 (April 2019) : 3337-3341. DOI. © 2019 American Chemical Society. Used with permission.

Recommended Citation

Arachchige, Pandula T. Kirinde and Yi, Chae S., "Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines" (2019). Chemistry Faculty Research and Publications. 1002.
https://epublications.marquette.edu/chem_fac/1002