Catalytic Transfer Deuteration and Hydrodeuteration: Emerging Techniques to Selectively Transform Alkenes and Alkynes to Deuterated Alkanes

Authors

Zoua Pa Vang, Marquette University
Samuel J. Hintzsche, Marquette University
Joseph R. Clark, Marquette UniversityFollow

Document Type

Article

Publication Date

7-12-2021

Publisher

Wiley

Source Publication

Chemistry - A European Journal

Source ISSN

0947-6539

Original Item ID

10.1002/chem.202100635

Abstract

Increasing demand for deuterium-labeled organic molecules has spurred a renewed interest in selective methods for deuterium installation. Catalytic transfer deuteration and transfer hydrodeuteration are emerging as powerful techniques for the selective incorporation of deuterium into small molecules. These reactions not only obviate the use of D₂ gas and pressurized reaction setups but provide new opportunities for selectively installing deuterium into small molecules. Commercial or readily synthesized deuterium donors are typically employed as easy-to-handle reagents for transfer deuteration and hydrodeuteration reactions. In this minireview, recent advances in the catalytic transfer deuteration and hydrodeuteration of alkenes and alkynes for the selective synthesis of deuterated alkanes will be discussed.

Comments

Accepted version. Chemistry - A European Journal, Vol. 27, No. 39 (July 12, 2021): 9988-10000. DOI. © 2021 Wiley. Used with permission.

Recommended Citation

Vang, Zoua Pa; Hintzsche, Samuel J.; and Clark, Joseph R., "Catalytic Transfer Deuteration and Hydrodeuteration: Emerging Techniques to Selectively Transform Alkenes and Alkynes to Deuterated Alkanes" (2021). Chemistry Faculty Research and Publications. 1060.
https://epublications.marquette.edu/chem_fac/1060