Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents
Document Type
Article
Publication Date
2024
Publisher
American Chemical Society
Source Publication
ACS Omega
Source ISSN
2470-1343
Original Item ID
DOI: 10.1021/acsomega.3c09721
Abstract
Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation of sterols. This article describes an efficient synthesis of a library of thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied for their antineoplastic and antibacterial properties, which led to the discovery of hit compounds with therapeutic potential. The antibacterial compound is noncytotoxic and nonhemolytic against cancer cell lines and sheep red blood cells, respectively. Several of the antineoplastic compounds showed activity against human cancer cell lines with growth inhibition at submicromolar concentration.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Roy, Subrata; Raj, Hansa KC; Adhikary, Sanjay; Erickson, Alexander N.; and Alam, Mohammad Abrar, "Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents" (2024). Chemistry Faculty Research and Publications. 1103.
https://epublications.marquette.edu/chem_fac/1103
Comments
ACS Omega, Vol. 9, No. 22 (2024): 23283-23293. DOI.