Flash Communication: Visible-Light-Driven, Cobalt-Mediated Selective C–H Arylation of 2,2′-Bipyridine

Authors

• Xi Chen, Marquette University
• Eric R. Allen, Marquette University
• McKenzie L. Stack, Marquette University
• Zachary M. Garozzo, Marquette University
• Dian Wang, Marquette UniversityFollow

Document Type

Article

Publication Date

8-25-2025

Publisher

American Chemical Society

Source Publication

Organometallics

Source ISSN

0276-7333

Original Item ID

DOI: 10.1021/acs.organomet.5c00204

Abstract

Herein, we report a visible-light-driven, cobalt-mediated, highly selective C–H arylation method to afford aryl-2,2′-bipyridine, a widely used class of ancillary ligands in transition metal catalysis. This arylation reaction exhibits good-to-excellent C6 selectivity for a variety of aryl groups, allowing for isolation of the 6-isomer in its pure form. Mechanistic studies provided evidence for the generation of an aryl radical by the joint action of [Co(bpy)₃] species and visible light, enabling arylation under mild conditions. Compared to previous work, this method employs cost-effective reagents and provides one-step, direct access from 2,2′-bipyridine to a broad range of electronically varied 6-aryl-2,2′-bipyridine products.

Comments

Accepted version. Organometallics, Vol. 44, No. 16 (August 25, 2025): 1735-1739. DOI. © 2025 American Chemical Society. Used with permission.

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Recommended Citation

Chen, Xi; Allen, Eric R.; Stack, McKenzie L.; Garozzo, Zachary M.; and Wang, Dian, "Flash Communication: Visible-Light-Driven, Cobalt-Mediated Selective C–H Arylation of 2,2′-Bipyridine" (2025). Chemistry Faculty Research and Publications. 1110.
https://epublications.marquette.edu/chem_fac/1110