Oxidative Ionic Metabolites of 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine (MPTP): Correlation of Electroreduction with Physiological Behavior

Authors

James R. Ames, University of Wisconsin - Milwaukee
N. Castagnoli Jr.
Michael D. Ryan, Marquette UniversityFollow
Peter Kovacic, University of Wisconsin - Milwaukee

Document Type

Article

Language

eng

Publication Date

1986

Publisher

Elsevier

Source Publication

Free Radical Biology and Medicine

Source ISSN

0891-5849

Abstract

Electrochemical studies (reduction potential and reversibility) were performed on 1-methyl-4-phenylpyridinium (MPP+) and 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). MPP+ gave reduction potentials in the range of -1.09 to -1.11 V in organic solvents in a process which was reversible. The reduction potential of MPDP+ was -0.64 V (irreversible). Possible relationships involving the electrochemical properties, oxy radical formation, and biological activity of these and related iminium species are discussed.

Comments

Free Radical Biology and Medicine, Vol. 2 (1986): 107-113. Publisher Link.

Recommended Citation

Ames, James R.; Castagnoli, N. Jr.; Ryan, Michael D.; and Kovacic, Peter, "Oxidative Ionic Metabolites of 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine (MPTP): Correlation of Electroreduction with Physiological Behavior" (1986). Chemistry Faculty Research and Publications. 442.
https://epublications.marquette.edu/chem_fac/442